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market introduction, press reports and independent studies suggest that
side-effects occur stronger and more commonly than shown by the
manufacturer in their clinical studies.
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Alprazolam is hydroxylated in the liver to ?-hydroxyalprazolam, which is
also pharmacologically active but much less so than the parent
compound.
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This is deemed to result from the drug's being active in the central
nervous system, an area of human physiology so complex that the effects
of a drug are extremely difficult to predict or
anticipate.
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the time of his anticipated sexual activity, Lilly ICOS began a clinical
development program to evaluate the risks and benefits of chronic,
once-daily use of the drug.
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Currently, sildenafil (trade name Revatio) is approved in several world
regions as a thrice-daily therapy for pulmonary arterial
hypertension.