Black Sesame Extract sesamin


sesamin Black Sesame Extract Sesamum indicum L





sesamin Herb Source
Sesamum indicum L. Zanthoxylum acanthapodium var. villosum Huang. Piper longum

sesamin Molecular Formula and Molecular Weight
C20H18O6

351.34


sesamin Melting Point
122 -123

sesamin Solubility
sesamin Freely soluble in chloroform-benzene-acetic acid and acetone.



sesamin Pharmacology
Antioxidant Bactericide Insecticide Non-competitive D5-desaturase inhibitor.
Sesamin is an all-natural component stored in sesame seeds. Its content is only about 0.5 percent. Through extracting sesamin from sesame, and experimenting in animals and humans, the Japanese scientific researchers have discovered that sesamin has effects of preventing hypertension and cardiovascular hypertrophy, protecting liver, resisting oxidation, reducing cholesterol, and anti-cancer .

Effect of sesamin, a sesame lignan, on the hepatic fatty acid metabolism was examined in the rat.
Increase of the dietary level of sesamin progressively increased the mitochondrial and peroxisomal
fatty acid oxidation rate. Mitochondrial activity almost doubled in rats fed a 0.5% sesamin diet. Peroxisomal
activity became more than 10 times higher in rats fed a 0.5% sesamin diet, compared to those
fed a sesamin-free diet. Dietary sesamin also markedly increased the hepatic activity and mRNA levels
of various fatty acid oxidation enzymes. In contrast, dietary sesamin decreased the hepatic activity
and mRNA abundance of lipogenic enzymes. This was associated with the down-regulation of sterol
regulatory element-binding protein-1, a transcriptional factor that regulates the lipogenic enzyme gene
expression. Dietary sesamin significantly decreased the triacylglycerol secretion accompanying the
increase in ketone body production by the perfused rat liver. It is apparent that sesamin affects the fatty
acid metabolism and lipoprotein production in the liver, and hence lowers the serum lipid levels. We
also developed several sesame lines with seeds containing sesamin and sesamolin at twice the concentration
of conventional cultivars. Compared to a conventional cultivar, these lignan-rich sesame seeds
increased the hepatic fatty acid oxidation rate and lowered the serum triacylglycerol level in the rat.
Therefore, it is considered that enrichment of the lignans potentiates the characteristics of sesame in
improving human health.

Sesamin, one of the lignans present most abundantly
in sesame seed and oil (Fig. 1), markedly influences the
lipid metabolism in experimental animals. Sesamin feeding
is associated with a reduction of serum lipid levels in
rodents7,8,22. This compound is also effective in preventing
an increase in the serum triacylglycerol level following
ethanol consumption in the rat1. The cholesterollowering
effect of sesamin has also been demonstrated in humans6. However, the mechanism(s) underlying the
lipid-lowering effect of sesamin remains to be clarified.
The changes in the rate of fatty acid synthesis and oxidation
in the liver may possibly modify serum lipid concentrations.
Alterations in fatty acid synthesis25 and
oxidation10,11 which affect the availability of fatty acids
for triacylglycerol synthesis, and in turn modify the very
low density lipoprotein production by the liver, may
affect the serum lipid levels. In this context, we examined
the physiological activity of sesamin in relation to
the hepatic fatty acid metabolism in the rat.

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