Broccoli Extract
Broccoli Extract
Brassica oleracea Botrytis cymosa Sulforaphane indole-3-carbinol
Broccoli Extract Brassica oleracea Botrytis cymosa Sulforaphane
indole-3-carbinol
Indole-3-carbinol (I3C) is a secondary metabolite found in cruciferous
vegetables such as broccoli, cauliflower, kale, cabbage and brussels
sprouts. A secondary metabolite is one not found preformed in
vegetables, but formed after an enzyme in the vegetable (myrosinase) is
exposed to a phytochemcial in the vegetable (glucobrassicin). This can
occur only when vegetable cells are crushed or eaten, and is referred to
as enzymatic hydrolysis.
I3C, thus formed, is then broken down in the presence of acid (as in the
acid environment of the stomach) to various by-products such as
diindolylmethane (DIM), which are then absorbed.
Why is this important? Because I3C has been
shown to inhibit cancer cells in animal cancer models of the mammary,
liver, and lung.5-7 It is currently being evaluated in human clinical
trials as a potential chemopreventive agent against breast and ovarian
cancers.8
I3C appears to
work by upregulating or modulating certain enzymes that improve the
detoxification of various potential carcinogens¢®¨£although it appears
to be the breakdown products that have this effect rather than IC3
itself. Furthermore, it is not clear that DIM is the only breakdown
product of importance.9
Certainly DIM by itself has an effect, but these other products may also
be important for the overall cancer-inhibiting action. As most of the
research to date has focused on I3C, it seems prudent at this time to
use supplements containing I3C instead of DIM. Just make sure you take
it with meals and have sufficient acidifying capacity in your stomach.
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